Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.
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Factors that may contribute to the protection of mucosa, such as mucus and bicarbonate secretion are dependent on gastric blood flow Guth et al.
Thirty minutes later, all the rats in groups 2—6 were treated with piroxicam. Shows ulceration of mucosa layer of group treated with ethanol only Magnification X Introduction Nonsteroidal anti-inflammatory drugs NSAIDswhich act as non-selective cyclooxygenase COX inhibitors, are commonly used to treat pain and inflammation despite the risk of major upper gastrointestinal complications Venkova et al.
Discussion The results obtained from the study showed that the methanolic stem bark extract of Crossopteryx febrifuga possess anti-ulcerogenic activity in rats. Pharmacological studies of Panacis japonici Rhizoma. Fresh stem bark of C. Preparations of Crossopteryx febrifuga Afzel. The number of deaths in each group within 24 h was recorded and the final LD 50 values were calculated as the geometric mean of the highest nonlethal dose with no deaths and the lowest lethal dose where deaths occurred.
The technical assistance of the Staff of Animal Facility center is highly appreciated. Ethanol produced haemorrhagic gastric lesions mainly in the glandular segment of the stomach mucosa.
West African Plants
The stomachs were removed, opened along the greater curvature, rinsed with slow running water. Chemical febrofuga Pharmaceutical Bulletin. Traditional Complementary and Alternative Medicines Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats.
Pharmacological screening and crossopteryd. Preventive ratio PR defined as the degree of protection offered by a treatment against ulcer causing agent was calculated using the formula:. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions.
Table 1 Effect of Crossopteryx febrifuga on ethanol-induced gastric ulceration in rats. Anti-ulcer drugs of plant origin.
Flora of Zimbabwe: Species information: Crossopteryx febrifuga
It is known that ethanol produces necrotic lesions in the gastric mucosa by its direct toxic effect, by reducing both secretion of bicarbonates and production of mucus Marhuenda et al. The stem bark was cleaned, air-dried for seven 7 days and crushed into coarse powder using a pestle and mortar.
Oxygen free radicals and lipid peroxidation Takeuchi et al. These results showed that the extract had no deleterious effects and was cytoprotective on the gastrointestinal tract git. Table 3 Results of Histopathology examinations. The primary cause of the pathogenic effects of NSAIDs in the stomach is the deficiency of endogenous prostaglandins required to maintain the mucosal barrier to luminal acid. Previous studies have shown that some tannins Salawu et al.
One hour after ethanol administration, the rats were sacrificed under diethyl ether anaesthesia. One of such therapeutically useful medicinal plant is Crossopteryx febrifuga Benth, Family Rubiaceaea twisted tree with conspicuous tubular flowers, which is widely distributed throughout the Savannah region of Central, East and West Africa. These were then examined by a consultant histopathologist. In conclusion this study illustrated the safety of Crossopteryx febrifuga in gastrointestinal tract when used as an antiinflammatory analgesic agent that could be developed for management of painful inflammatory disorders.
Six hours after piroxicam administration, the rats in all the groups were sacrificed under diethyl ether anesthesia. The results obtained showed that the methanolic stem bark extract of Crossoptery febrifuga possesses significant antiulcer effect against ethanol- induced gastrointestinal ulceration in rats. Thus, illustrating the pharmacodynamic safety of the extract even in painful conditions associated with gastro-intestinal ulceration. The products of the 5-lipoxygenase pathway may also play a key role in the development of ulcer induced by irritant agents such as ethanol Lange et al.
The phytochemical analyses carried out on methanolic stem bark extract of Crossopteryx febrifuga by Salawu et al. Author information Copyright and License information Disclaimer. Misoprostol a synthetic analogue of prostaglandin E1 completely protected the mucosal layer against piroxicam-induced lceration. Preparation of the plant extract The stem bark was cleaned, air-dried for seven 7 days and crushed into coarse powder using a pestle and mortar.
Relation to gastric hypermotility. Indian J Physiol Pharmacol. Finally, the flavonoids are the major secondary metabolites class with several descriptions of antiulcer, antioxidant and gastroprotective properties, which involves nitric oxide participation Matsuda et al.
Materials and Methods Collection plant material Fresh stem bark of C.
Piroxicam-induced gastric ulceration The method described by Salawu et al. These rats were also observed for signs of toxicity and mortality for the first critical 4h and thereafter daily for 7 days.
Nonsteroidal anti-inflammatory drugs NSAIDswhich act as non-selective cyclooxygenase COX inhibitors, are commonly used to treat pain and inflammation despite the risk of major upper gastrointestinal complications Venkova et al. Yesilada E, Takaishi Y.