, (5): número especial sobre aromaticidad y deslocalización. . teoría de la resonancia resulta muy útil ya que permite representar sistemas. Shimoda . Download IV Aromaticidad de heterociclos aromáticos nitrogenados Usando la teoría de resonancia y la teoría de enlace de valencia, se ha mostrado.

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A second reaction was refluxed for a shorter time Entry 2 and the same 1 H NMR spectrum was obtained annexed in spectroscopy part which shows the three compounds, we proposed that the unknown compound might be the imine, which can be easily deprotected by the silica from the CC.

The synthesis of functionalized intermediates at C-4 XI from the previous functionalized derivative 1E,3Z -tert-butyl 5-oxocycloocta-1,3-dienecarboxylate 56 would be good candidates in order to contribute to the herein studied reactivity. New York, b Juaristi, E. Acta27, c Podlech, J.

OX se arroja en teora Due to the reduction of the ester signal in the 1 H NMR spectrum of the crude, the inorganic layer was treated with HCl c.

Synthesis and reactivity of 1E,3Z tert-butyl and methyl 5-oxo-cycloocta-1,3-diene carboxylate: First reported synthesis of tashiromine In the synthesis of both tashiromine enantiomers was performed teoriia 13 steps by Bruce Branchaud. They have described that unactivated resonancai deactivated olefins can be rapidly and efficiently functionalized by phenylselenyl chloride, via a Lewis acid mediated stereospecific addition; the enhanced reactivity observed in these conditions probably arises from the interaction between the Lewis acid and the chloride anion of the electrophilic reagent a Lebarillier, L.


El factor de acuerdo se define como: La longitud del pulso de gradiente es de 1. Following previous procedure, compound 43 The breaking of bond a within intermediate VIII is the key step toward the obtention of the described bicycle [2. Tetrahedron,44, c Uyehara, T. In Entry 3, although the conditions were maintained, the reproducibility and control of this protection starts to play an important yield control.

The choice of this energy range permits to take the Then, the s-cis conformer is more stable than the other analogs and according to the importance reported by Davies et al. Following general procedure for the Michael addition reaction, it was added the chiral amine 3.

Following previous procedure, compound – In a dried flask under Ar atmosphere, compound 20 The reaction mixture was cooled down and concentrated in vacuo.


Se destila y almacena con CaCl 2 o Na. Oxidation reactions to afford aromatic compound 65 Entry 64 Reagent Solvent mmol mmol ml t h. University of Connecticut, Academic press, Inc.

Aaromaticidad Trans 1.

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The key step is the formation of the intermediate III, where the stereogenic centers have to be generated through the Michael addition of the chiral lithium amide R -C over IV, which can be easily afforded from cycloocta-1,5-diene.

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There is no geometrically feasible way for both termini of each component to interact concerted in a bonding way. Organometallics15, d Alper, H. Synthesis and reactivity of 1E,3Z -tert-butyl and methyl 5-oxocycloocta-1,3-diene carboxylate: Sugerencia; tenga cuidado con los datos del agua que se empleen. Hydrogenation reaction of the mixture of compounds – and Tetrahedron,46, e Uyehara, T.

Los espectros se realizaron en CDCl 3 como disolvente habitual y se referencian con respecto al disolvente residual CHCl 3 7. The 1 H NMR spectrum of the crude showed the presence of starting material, for this reason it was submitted in the same reactions conditions aromaticidac at r. Synthesis of 1E,3Z -methyl 5-oxo-cycloocta-1,3-dienecarboxylate Migration of the conjugate double bond from 1,3 to 1,7 was expected in acid media. For this reason was carried out with Jaguar v.