AMILOIDOSIS MACULAR PDF

Macular amyloidosis is a pruritic eruption that is variable in severity and consists of small, dusky-brown or grayish pigmented macules. Macular amyloidosis (MA) is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly. CASE REPORT. An unusual presentation of macular amyloidosis. Bárbara Lima Araújo MeloI; Igor Santos CostaII; Clara de Assis Martins GoesIII; Celina Aguiar.

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Various systemic and cutaneous diseases in association with MA in our patients were chronic urticaria, diabetes mellitus, acne vulgaris, generalized xeroderma, hypothyroidism, hypertension and idiopathic hirsutism. Role of friction was inconclusive. Representative biopsy of macular or lichen amyloid.

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Orphanet: Amiloidosis macular

How to cite this article. Sun exposure did seem to play an important role in the localization of disease. Specialised Social Services Eurordis directory. Accessed December 31st, Histopathological examination of the cutaneous lesion revealed significant quantities of an amyloid deposit in the papillary dermis, which could be more clearly observed after Congo red staining, as well as foci of mzcular incontinence.

However, small amounts of amyloid may not be detected maclar methyl violet and Congo red staining, which can complicate the diagnosis of macular amyloidosis.

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There is a strong association between localized cutaneous amyloidosis and amiloidowis paresthetica. These changes did not always correlate with the deposition of amyloid and extended well beyond the areas of amyloid deposits.

J Am Acad Dermatol. Accessed April 27, Various risk factors such as, race,[ 28 ] female gender,[ 3610 ] genetic predisposition,[ 13 ] sun exposure,[ 12 ] atopy[ 14 ] and friction[ 1215 — 17 ] have been implicated in the etiopathogenesis of MA. In order to differentiate macular amyloidosis from other skin disorders, the presence of amyloid must be confirmed. This content does not have an English version. Dermabrasion for lichen amyloidosus: If amyloid affects the nerves that control your bowel function, you may experience periods of alternating constipation and diarrhea.

Summary and related texts.

A Clinico-Epidemiological Study of Macular Amyloidosis from North India

Click here for information on linking amiooidosis our website or using our content or images. Structures and biological functions of IL and IL receptors. Mayo Clinic, Rochester, Minn. In the patient studied here this failed to reveal any abnormal results.

Etretinate for the treatment of lichen amyloidosis. Lichen amyloidosus without itching indicates that it is not secondary to chronic scratching. Contrary to previous reports, MA in our study was observed in a majority of patients of comparatively lighter skin than in those with a higher skin phototype.

MA is commonly associated with other skin diseases, such as atopic dermatitis. Footnotes Source of Support: Unusual Clinical Scenarios to Consider in Patient Management There is an unclear link between primary localized cutaneous amyloidoses and a variety of immune disorders including systemic sclerosis, CREST syndrome, rheumatoid arhritis, systemic lupus erythematosus, primary biliary cirrhosis, autoimmune cholangitis, Kimura disease, ankylosing spondylitis, autoimmune thyroiditis, IgA nephropathy, and sarcoidosis.

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It also highlights the need for further studies to amiloiddosis the etiopathogenesis of PCA with a view to finding effective treatment for this type of cutaneous amyloidosis. An assessment of prevalence, sex, and age.

No sponsor mzcular advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. Frequent association between MEN 2A and cutaneous lichen amyloidosis. Services on Demand Journal. Maurer MS, et al. Lack of clear-cut etiological factors makes it difficult to suggest a reasonable therapeutic modality. It has been suggested that female preponderance maybe due to medical attention sought earlier by women for the cosmetically disturbing pigmentation.

There are no clear guidelines for monitoring therapy for patients with macular amyloidosis. Intermittent use of topical dimethyl sulfoxide in macular and papular amyloidosis. Lichen amyloidosis associated with atopic dermatitis: Notalgia paraesthetica–report of an association with macular amyloidosis.

The literature on the subject is also reviewed.